Brain Injury due to Mechanical Trauma and Ischemic-Hypoxic Insult: Biomarkers of Brain Injury and Oxidative Stress

Brain Injury due to Mechanical Trauma and Ischemic-Hypoxic Insult: Biomarkers of Brain Injury and Oxidative Stress

Hypoxic-Ischemic Brain Injury in Piglets

Background and Purpose: The excitatory amino acid inhibitor MK-801 has been shown in many animals species to protect against hypoxic-ischemic brain injury. We sought to determine whether hypoxic-ischemic injury to the newborn pig's brain could be prevented by the use of MK-801. Methods: Hypoxic-ischemic injury to the brain was induced in forty 0-3-day-old piglets. They were randomized to receiv...

The role of oxidative stress in perinatal hypoxic-ischemic brain injury.

INTRODUCTION The pathogenesis of perinatal hypoxic-ischemic brain damage is highly complex. OBJECTIVE The aim of this study was to assess the role of oxidative stress in hypoxic-ischemic brain injury and subsequent abnormal neurological outcome in infants with perinatal hypoxic-ischemic encephalopathy (HIE). We estimated perinatal oxidative brain damage measuring activity of glutathione perox...

Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury.

Hypoxic-ischemic (HI) brain injury in infants is a leading cause of lifelong disability. We report a novel pathway mediating oxidative brain injury after hypoxia-ischemia in which C1q plays a central role. Neonatal mice incapable of classical or terminal complement activation because of C1q or C6 deficiency or pharmacologically inhibited assembly of membrane attack complex were subjected to hyp...

Prediction of Clinically Important Traumatic Brain Injury in Pediatric Minor Head Trauma; proposing Pediatric Traumatic Brain Injury (PTBI) Prognostic Rule

Background: The present study assesses independent predictors of clinically important traumatic brain injury (ciTBI) in order to design a prognostic rule for identification of high risk children with mild head injury. Materials and Methods: In a retrospective cross-sectional study, 3,199 children with mild traumatic brain injury (TBI) brought to emergency ward of three hospitals in Tehran, Iran...